LINZESS may relieve your IBS‑C or CIC symptoms by helping you feel less belly pain and have more frequent 
                and complete bowel movements that are easier to pass.

Is it CIC?

How do you know whether you have occasional constipation or Chronic Idiopathic Constipation?

Everyone wants to be regular. But the definition of regular is different for everyone. For some, it's several times a day. For others, it could be several times a week. If you are having fewer than three bowel movements a week, that's a sign you may have constipation. But is it occasional or chronic?

If the symptoms of your constipation are sudden or last for a short time it may be occasional constipation. If the symptoms keep coming back and seem to last for a long time, it may be chronic constipation. If you notice you're having infrequent bowel movements, difficulty passing stools, or both, that may mean you're suffering from Chronic Idiopathic Constipation (CIC). You should share these symptoms with your doctor.

What is CIC?

Almost everyone experiences constipation at some point in their lives. But if your constipation is long-lasting or keeps coming back, it may be chronic. Chronic constipation without an identifiable cause is often referred to as Chronic Idiopathic Constipation (CIC). "Idiopathic" means the cause is unknown. CIC is generally defined as infrequent bowel movements, difficulty passing stools, or both.

While estimates vary, as many as 35 million adults in the U.S. may suffer from CIC.

A recent survey showed that patients
with CIC reported most frequently:

  • Constipation symptoms
  • Hard or lumpy stools
  • Straining during bowel movements
  • Incomplete bowel movements

CIC patients may also suffer from:

  • Stomach cramping
  • Gas pain
  • Bloating

What factors may contribute to CIC?

There are several factors that may contribute to the development of CIC.

Linzess Is It IBS-C Icon Fluid Absorption

Fluid absorption: The colon may be absorbing too much fluid from the stool. This can result in the formation of hard stools that are difficult to pass.

Linzess Is It CIC Icon Muscle Contractions

Muscle contractions: The muscles of the colon may be contracting too slowly, which can reduce the movement of stool through the colon and cause infrequent stools.

Linzess Is It CIC Icon

Decreased urge: Some patients may have less sensitivity, which may reduce the urge to have a bowel movement. Other patients may have extra sensitive nerves, which can cause discomfort.

To help find relief, share your symptoms with your doctor.

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What is LINZESS?

LINZESS® (linaclotide) is a prescription medication used in adults to treat irritable bowel syndrome with constipation (IBS‑C) and chronic idiopathic constipation (CIC). "Idiopathic" means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children.

Important Risk Information
  • Do not give LINZESS to children who are under 6 years of age. It may harm them.
  • You should not give LINZESS to children 6 to 17 years of age. It may harm them.
  • Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).
Before you take LINZESS, tell your doctor:
  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
  • If you are breastfeeding or plan to breastfeed. It is not known if LINZESS passes into your breast milk.
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Side Effects

LINZESS can cause serious side effects, including diarrhea, the most common side effect, which can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.

Other common side effects of LINZESS include gas, stomach-area (abdominal) pain, swelling, or a feeling of fullness or pressure in your abdomen (distension). Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist.

In addition, call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdominal) pain, especially if you also have bright red, bloody stools or black stools that look like tar.

Please also see Medication Guide within full Prescribing Information.

*This offer is valid only for patients with LINZESS prescriptions. Depending on insurance coverage, most eligible patients may pay as little as $30 per prescription fill for each of up to 12 prescription fills. Check with your pharmacist for your copay discount. Maximum savings limit applies; patient out-of-pocket expense may vary. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. This offer is not valid for cash‑paying patients. Please see full Program Terms, Conditions, and Eligibility Criteria on our Saving on LINZESS page.

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What is LINZESS?

LINZESS® (linaclotide) is a prescription medication used in adults to treat irritable bowel syndrome with constipation (IBS‑C) and chronic idiopathic constipation (CIC). "Idiopathic" means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children.

Important Risk Information
  • Do not give LINZESS to children who are under 6 years of age. It may harm them.
  • You should not give LINZESS to children 6 to 17 years of age. It may harm them.
  • Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).
Before you take LINZESS, tell your doctor:
  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
  • If you are breastfeeding or plan to breastfeed. It is not known if LINZESS passes into your breast milk.
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Side Effects

LINZESS can cause serious side effects, including diarrhea, the most common side effect, which can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.

Other common side effects of LINZESS include gas, stomach-area (abdominal) pain, swelling, or a feeling of fullness or pressure in your abdomen (distension). Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist.

In addition, call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdominal) pain, especially if you also have bright red, bloody stools or black stools that look like tar.

Please also see Medication Guide within full Prescribing Information.

*This offer is valid only for patients with LINZESS prescriptions. Depending on insurance coverage, most eligible patients may pay as little as $30 per prescription fill for each of up to 12 prescription fills. Check with your pharmacist for your copay discount. Maximum savings limit applies; patient out-of-pocket expense may vary. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. This offer is not valid for cash‑paying patients. Please see full Program Terms, Conditions, and Eligibility Criteria on our Saving on LINZESS page.