LINZESS may relieve your IBS‑C or CIC symptoms by helping you feel less belly pain and have more frequent 
                and complete bowel movements that are easier to pass.

Is it IBS-C?

How do you know whether you have occasional or chronic constipation?

Everyone wants to be regular. But the definition of regular is different for everyone. For some, it's several times a day. For others, it could be several times a week. If you are having fewer than three bowel movements a week, that's a sign you may have constipation. But is it occasional or chronic?

If the symptoms of your constipation are sudden or last for a short time, it may be occasional constipation. If the symptoms keep coming back and seem to last for a long time, it may be chronic constipation. If you describe your symptoms as either belly pain or discomfort associated with your constipation, you could be suffering from Irritable Bowel Syndrome with Constipation (IBS‑C). You should share all your symptoms with your doctor.

What is IBS-C?

IBS‑C is defined as belly pain (abdominal pain) or discomfort associated with constipation. The symptoms of IBS‑C are defined as long-lasting and keep coming back. Those suffering from IBS‑C also have hard or lumpy stools at least 25% of the time, and loose or watery stools less than 25% of the time.

While estimates vary, as many as 13 million adults in the U.S. may suffer from IBS‑C.

What causes IBS‑C?

The causes are unknown, but researchers believe there may be several factors involved.

Linzess Is It IBS-C Icon Nerves

Sensitive nerves: The nerves in the intestines may be extra sensitive, causing sufferers to feel more belly pain or discomfort than those who do not have IBS‑C.

Linzess Is It IBS-C Icon Fluid Absorption

Fluid absorption: The colon may be absorbing too much fluid from the stool, or the muscles in the colon may be moving too slowly. This can cause the stool to become dry, hard, and difficult to pass.

Linzess Is It IBS-C Icon

Brain-bowel connection: There could be miscommunication between the brain and the bowel (gut), which may cause belly pain, discomfort, and a change in bowel movements.

To help find relief, share your symptoms with your doctor.

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What is LINZESS?

LINZESS® (linaclotide) is a prescription medication used in adults to treat irritable bowel syndrome with constipation (IBS‑C) and chronic idiopathic constipation (CIC). "Idiopathic" means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children.

Important Risk Information
  • Do not give LINZESS to children who are under 6 years of age. It may harm them.
  • You should not give LINZESS to children 6 to 17 years of age. It may harm them.
  • Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).
Before you take LINZESS, tell your doctor:
  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
  • If you are breastfeeding or plan to breastfeed. It is not known if LINZESS passes into your breast milk.
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Side Effects

LINZESS can cause serious side effects, including diarrhea, the most common side effect, which can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.

Other common side effects of LINZESS include gas, stomach-area (abdominal) pain, swelling, or a feeling of fullness or pressure in your abdomen (distension). Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist.

In addition, call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdominal) pain, especially if you also have bright red, bloody stools or black stools that look like tar.

Please also see Medication Guide within full Prescribing Information.

*This offer is valid only for patients with LINZESS prescriptions. Depending on insurance coverage, most eligible patients may pay as little as $30 per prescription fill for each of up to 12 prescription fills. Check with your pharmacist for your copay discount. Maximum savings limit applies; patient out-of-pocket expense may vary. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. This offer is not valid for cash‑paying patients. Please see full Program Terms, Conditions, and Eligibility Criteria on our Saving on LINZESS page.

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What is LINZESS?

LINZESS® (linaclotide) is a prescription medication used in adults to treat irritable bowel syndrome with constipation (IBS‑C) and chronic idiopathic constipation (CIC). "Idiopathic" means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children.

Important Risk Information
  • Do not give LINZESS to children who are under 6 years of age. It may harm them.
  • You should not give LINZESS to children 6 to 17 years of age. It may harm them.
  • Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).
Before you take LINZESS, tell your doctor:
  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
  • If you are breastfeeding or plan to breastfeed. It is not known if LINZESS passes into your breast milk.
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Side Effects

LINZESS can cause serious side effects, including diarrhea, the most common side effect, which can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.

Other common side effects of LINZESS include gas, stomach-area (abdominal) pain, swelling, or a feeling of fullness or pressure in your abdomen (distension). Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist.

In addition, call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdominal) pain, especially if you also have bright red, bloody stools or black stools that look like tar.

Please also see Medication Guide within full Prescribing Information.

*This offer is valid only for patients with LINZESS prescriptions. Depending on insurance coverage, most eligible patients may pay as little as $30 per prescription fill for each of up to 12 prescription fills. Check with your pharmacist for your copay discount. Maximum savings limit applies; patient out-of-pocket expense may vary. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. This offer is not valid for cash‑paying patients. Please see full Program Terms, Conditions, and Eligibility Criteria on our Saving on LINZESS page.