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A male professor with IBS-C (Irritable Bowel Syndrome with Constipation) listening as a female student reads from a book. A male professor with IBS-C (Irritable Bowel Syndrome with Constipation) listening as a female student reads from a book.

HOW TO TAKE LINZESS

WHY TAKING LINZESS AS DIRECTED MATTERS

For adults with Irritable Bowel Syndrome with Constipation (IBS-C) or Chronic Idiopathic Constipation (CIC)

Once you’ve been prescribed LINZESS, it’s important to stay on top of your treatment: If you stop taking your medication, your symptoms could return in about a week. Take the medication as recommended by your doctor and keep them informed about your experience with LINZESS.

TAKE LINZESS…

An icon of a pill capsule. An icon of a pill capsule. An icon of a pill capsule.

… EVERY DAY For LINZESS to work best, take it every day. This is different from over-the-counter laxatives, which are often taken as needed.

When LINZESS is taken daily, constipation relief is typically felt in about 1 week. IBS-C patients may begin to experience relief of belly pain and overall abdominal symptoms* (pain, discomfort, and bloating) in about 1 week, with symptoms typically improving over 12 weeks.

*Abdominal symptoms were studied in combination, not individually.

An icon of a daily calendar with the number one on it to represent taking LINZESS once daily.An icon of a daily calendar with the number one on it to represent taking LINZESS once daily.An icon of a daily calendar with the number one on it to represent taking LINZESS once daily.

… ONCE A DAY If you miss a dose, take your dose as usual the following day. Do not take 2 doses at the same time to make up for a missed dose.

An icon of an empty anatomical stomach to represent taking LINZESS on an empty stomach 30 minutes before your first meal. An icon of an empty anatomical stomach to represent taking LINZESS on an empty stomach 30 minutes before your first meal. An icon of an empty anatomical stomach to represent taking LINZESS on an empty stomach 30 minutes before your first meal.

… ON AN EMPTY STOMACH Take your pill, as prescribed by your doctor, at least 30 minutes before your first meal of the day.

An icon of a glass full of water. An icon of a glass full of water. An icon of a glass full of water.

… WITH APPLESAUCE OR WATER, IF NECESSARY If you have trouble swallowing capsules, carefully open the LINZESS capsule and sprinkle all of the LINZESS beads onto applesauce or into 1 oz. (30mL) of water.

WHAT TO KNOW BEFORE STARTING LINZESS

Want to get off to the right start with LINZESS? Watch this short video where Dr. Darren Brenner shares 4 key points about how to take LINZESS and what to expect in terms of symptom relief and common side effects.

“The purpose of this short video is to provide you with some important clinical information that may assist you in achieving a successful outcome when taking LINZESS.”

Dr. Darren Brenner,
Northwestern University Feinberg School of Medicine

GET TREATMENT TIPS, DAILY MEDICATION REMINDERS & MORE

Whether you already take LINZESS or are just starting treatment, get expert advice, helpful tools, and more by enrolling in our From The GutSM patient support program.

A heart shaped icon formed by two hands holding to represent signing up to receive tips, information, recipes, and more. A heart shaped icon formed by two hands holding to represent signing up to receive tips, information, recipes, and more. A heart shaped icon formed by two hands holding to represent signing up to receive tips, information, recipes, and more.

SIGN UP FOR SUPPORT

You’ll receive a free From the GutSM digital cookbook featuring nutritionist-designed, gut-friendly recipes after joining!

SIGN UP
An icon of a ringing smartphone to represent enrolling to receive daily medication reminders. An icon of a ringing smartphone to represent enrolling to receive daily medication reminders. An icon of a ringing smartphone to represent enrolling to receive daily medication reminders.

GET DAILY REMINDERS

Text “ENROLL” to 70128* to sign up for your LINZESS reminder. After answering a few quick questions, you’ll receive daily SMS text reminders at the time of your choosing.

TEXT ENROLL TO 70128* External Website. Opens New WindowOpen a new window.

BE PROACTIVE WITH YOUR TREATMENT

An icon of a doctor's stethoscope to represent updating your doctor about how LINZESS is working for you. An icon of a doctor's stethoscope to represent updating your doctor about how LINZESS is working for you. An icon of a doctor's stethoscope to represent updating your doctor about how LINZESS is working for you.

UPDATE YOUR DOCTOR

It’s important to keep your doctor informed about how LINZESS is working for you. Let them know how it may be helping to manage your IBS-C or CIC symptoms and if you’re experiencing any side effects.

An icon of a medication bottle with a blank label to represent talking to your pharmacy for prescription refill reminders.An icon of a medication bottle with a blank label to represent talking to your pharmacy for prescription refill reminders.An icon of a medication bottle with a blank label to represent talking to your pharmacy for prescription refill reminders.

REFILL ON TIME

Your local pharmacy may offer refill reminders—ask your pharmacist about signing up. Can’t make it to the pharmacy for a while? Notify your doctor or pharmacist to ensure you have enough medication. You may also want to check if your pharmacy offers delivery services.

HOW TO STORE LINZESS

Remember to store LINZESS at room temperature (68°F-77°F). It's important to keep LINZESS in the bottle it comes in. Keep the LINZESS bottle tightly closed, in a dry place, and leave the desiccant (the drying agent that looks like a small cloth packet) in the bottle. Keep LINZESS out of the reach of children.

Please see Medication GuideOpen a new window. for full instructions.

*By texting ENROLL to 70128, you consent to receive automated and recurring text messages from From the GutSM regarding the From the GutSM program, including enrollment instructions, patient support communications and medication reminders, to the mobile phone number that you used to enroll. You are not required to consent or provide your consent as a condition of receiving any goods or services from From the GutSM. Message and data rates may apply. You also agree to the additional Terms and Conditions.Open a new window. Click AbbVie Privacy PolicyOpen a new window. for additional information about AbbVie’s privacy practices or click Ironwood Privacy PolicyOpen a new window. for more information about Ironwood Pharmaceuticals' privacy practices.

FROM THE GUTSM TIPS & RESOURCES
LINZESS SAVINGS PROGRAM
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IMPORTANT RISK INFORMATION

  • Do not give LINZESS to children who are less than 6 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
  • You should not give LINZESS to children 6 years to less than 18 years of age. It may harm them.
  • Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are:

  • Pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
  • Breastfeeding or plan to breastfeed. It is not known if LINZESS passes into your breast milk.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Side Effects

LINZESS can cause serious side effects, including diarrhea, the most common side effect, which can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.

Other common side effects of LINZESS include gas, stomach-area (abdominal) pain, swelling, or a feeling of fullness or pressure in your abdomen (distension). Call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdominal) pain, especially if you also have bright red, bloody stools or black stools that look like tar.

These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist.

What is LINZESS?

LINZESS® (linaclotide) is a prescription medication used in adults to treat irritable bowel syndrome with constipation (IBS‑C) and chronic idiopathic constipation (CIC). "Idiopathic" means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children less than 18 years of age.

Please also see Medication Guideopen pdf in new tab within Full Prescribing Information.open pdf in new tab

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IMPORTANT RISK INFORMATION

  • Do not give LINZESS to children who are less than 6 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
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