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HOW LINZESS WORKS

LINZESS CAN HELP PROACTIVELY MANAGE SYMPTOMS OF IBS-C & CIC

For adults with Irritable Bowel Syndrome with Constipation (IBS-C) or Chronic Idiopathic Constipation (CIC)

Diagram of exposed stomach demonstrating how LINZESS works.

LINZESS isn’t a laxative. It’s a once-daily capsule that can help you proactively manage symptoms of chronic constipation, including belly pain and overall abdominal symptoms associated with IBS-C.

LINZESS was the first approved treatment in a class of drugs that work differently than other medications. It acts locally in the intestine and is thought to work in 2 ways:

Lightning boltCalms pain-sensing nerves*

Downward-pointing arrow with wavy tail.Accelerates bowel movements

*This was seen in animal studies, and the relevance to humans is not known.

“After about a week of being on LINZESS, my bowel movements became more regular… and then, my pain started to subside.” Nan, 54
Diagnosed with IBS-C in 2010

LINZESS patient Nan, diagnosed with IBS-C in 2010. LINZESS patient Nan, diagnosed with IBS-C in 2010.

Blank monthly calendar with one day marked by an ‘X.’

WHEN CAN I EXPECT TO START SEEING MY SYMPTOMS IMPROVE WITH LINZESS?

When LINZESS is taken daily, constipation relief is typically felt in about 1 week. IBS-C patients may begin to experience belly pain and overall abdominal symptom relief in about 1 week, with symptoms typically improving over 12 weeks.

HOW TO TAKE LINZESS
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IMPORTANT RISK INFORMATION

  • Do not give LINZESS to children who are less than 6 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
  • You should not give LINZESS to children 6 years to less than 18 years of age. It may harm them.
  • Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are:

  • Pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
  • Breastfeeding or plan to breastfeed. It is not known if LINZESS passes into your breast milk.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Side Effects

LINZESS can cause serious side effects, including diarrhea, the most common side effect, which can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.

Other common side effects of LINZESS include gas, stomach-area (abdominal) pain, swelling, or a feeling of fullness or pressure in your abdomen (distension). Call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdominal) pain, especially if you also have bright red, bloody stools or black stools that look like tar.

These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist.

What is LINZESS?

LINZESS® (linaclotide) is a prescription medication used in adults to treat irritable bowel syndrome with constipation (IBS‑C) and chronic idiopathic constipation (CIC). "Idiopathic" means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children less than 18 years of age.

Please also see Medication Guideopen pdf in new tab within Full Prescribing Information.open pdf in new tab

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IMPORTANT RISK INFORMATION

  • Do not give LINZESS to children who are less than 6 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).