COULD IT BE IBS-C OR CIC? VIDEO TRANSCRIPT

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LINZESS logo with Uses and Safety Considerations, along with the first 2 bullets of ISI

USES

LINZESS^® (linaclotide) is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults and functional constipation (FC) in children and adolescents 6 to 17 years of age. “Idiopathic” means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children with functional constipation less than 6 years of age or in children with IBS-C less than 18 years of age.

SAFETY CONSIDERATIONS

Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Please see Important Safety Information including Boxed Warning at the end of the video.

Please see full Prescribing Information, including Boxed Warning, or visit Abbv.ie/LinzPI

AVO: We've brought together 3 people to talk about their experience with Irritable Bowel Syndrome with Constipation or IBS-C and Chronic Idiopathic Constipation or CIC.

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DEB | Prescribed LINZESS for IBS-C

JULIE | Prescribed LINZESS for CIC

PHIL | Prescribed LINZESS for IBS-C

AVO: From when they first started to feel symptoms to finding a treatment that worked for them—

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LINZESS Logo

Presents

AVO: —this is The Constipation Conversation. In this episode, Could it be IBS-C or CIC, our panel is sharing when they knew their gut issues were a serious problem.

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The Constipation Conversation logo

COULD IT BE IBS-C OR CIC?

EPISODE 1

DEB: I’ve had constipation for as long as I can remember. My doctor didn’t have answers. Would just say “drink prune juice.”

PHIL: They tell me I had a “nervous stomach.” But I was experiencing serious constipation.

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EXPERIENCING GUT ISSUES?

Visit Linzess.com/Constipation

JULIE: There wasn’t much in the way of treatment when I was young and going through it. I was always an athlete, so my doctors would assume because I was in such good shape it wasn’t a serious problem.

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EXPERIENCING GUT ISSUES?

Visit Linzess.com/Constipation

DEB: For me was a revolving door. I knew I had to eat. But I also knew it could come with constipation. I remember crying in the bathroom in pain because I couldn’t go.

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OCCASIONAL CONSTIPATION

Sudden or short periods of difficult, infrequent, or incomplete movements

PHIL: There's definitely a mental aspect as well. It's tough to get through your worst days.

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CHRONIC CONSTIPATION

Symptoms that keep coming back again and again

JULIE: And it's kind of hard to do what I want to do, whether I bike or swim.

PHIL: When I go out on a date with someone, lots of thoughts race through my mind. When I'm sitting down at a restaurant, for example, and it should be focused on the other person and I should be enjoying the other person’s company, but I am not able to do that.

JULIE: It made me have to plan everything to a tee, and I’d think, “Will I be able to go to this dinner if I’m constipated?”

PHIL: And then of course, as I got older, it got a little worse and it just kind of snowballed after that.

DEB: I was frustrated. Nothing seemed to work for the long haul. Thankfully, my family pushed me to keep looking for answers.

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See if your symptoms are more than occasional constipation. Visit Linzess.com/GutCheck

AVO: Watch episode 2 to hear more from our panel as they discuss how their frustrating journeys led them to push for LINZESS.

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The Constipation Conversation logo

NEXT UP:

SEEKING THE RIGHT TREATMENT

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USES

IMPORTANT RISK INFORMATION

Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are:

Pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
Breastfeeding or plan to breastfeed. You and your doctor should decide if you will take LINZESS and breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Side Effects

LINZESS can cause serious side effects, including diarrhea, which is the most common side effect and can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.

Other common side effects of LINZESS in people with IBS-C and CIC include gas, stomach-area (abdomen) pain, and swelling, or a feeling of fullness or pressure in your abdomen (distention).

Call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdomen) pain, especially if you also have bright red, bloody stools or black stools that look like tar.

These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie and Ironwood may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.

Please see full Prescribing Information, including Boxed Warning, or visit Abbv.ie/LinzPI

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Ironwood^® and its three-leaf design are registered trademarks of Ironwood Pharmaceuticals, Inc. LINZESS^® and its design are registered trademarks of Ironwood Pharmaceuticals, Inc.

*Third-party website; does not constitute an endorsement or recommendation by AbbVie. A fee will be charged by the telemedicine provider.

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IMPORTANT RISK INFORMATION

Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).

Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are:

IMPORTANT RISK INFORMATION

Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are: