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LINZESS logo with Uses and Safety Considerations, along with the first 2 bullets of ISI

USES

LINZESS^® (linaclotide) is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults and functional constipation (FC) in children and adolescents 6 to 17 years of age. “Idiopathic” means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children with functional constipation less than 6 years of age or in children with IBS-C less than 18 years of age.

SAFETY CONSIDERATIONS

• Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
• Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Please see Important Safety Information including Boxed Warning at the end of the video.

Please see full Prescribing Information, including Boxed Warning, or visit Abbv.ie/LinzPI

AVO: We've brought together 3 people to talk about their experience with Irritable Bowel Syndrome with Constipation or IBS-C and Chronic Idiopathic Constipation or CIC.

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DEB | Prescribed LINZESS for IBS-C

KIRK | Prescribed LINZESS for CIC

JULIE | Prescribed LINZESS for CIC

DR. SUSAN LUCAK, MD GASTROENTEROLOGIST

AVO: From when they first started to feel symptoms to finding a treatment that worked for them—

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LINZESS Logo

Presents

AVO: —this is The Constipation Conversation. This episode is all about talking to your doctor about your symptoms. To help guide the conversation, our panel is joined by special guest, Dr. Susan Lucak.

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The Constipation Conversation logo

GETTING ON THE SAME PAGE

EPISODE 3

DR. LUCAK: How hard was it for you to open up to your doctor at first?

KIRK: I feel like I really had to put myself out there for my doctor to take me seriously.

JULIE: There’s no easy way to talk about it. It can be embarrassing.

KIRK: As soon as I explained to him how bad my symptoms had gotten, he understood we needed to do more.

DR. LUCAK: That’s a great point Kirk. And did that conversation include talking about how these symptoms impact on your life?

KIRK: Oh yes, for sure.

DR. LUCAK: As doctors we’re trained to look for certain criteria. It helps us understand if someone’s constipation is a serious issue. What were some of your most bothersome symptoms?

JULIE: Not being able to go to the bathroom for days on end was the worst part. And being an athlete always made me more tense. So straining was an issue too.

DEB: I had frequent constipation. Every time I ate, I would feel bloated and in pain.

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• Constipation
• Straining
• Belly pain
• Discomfort
• Bloating

DR. LUCAK: That’s the type of information we need to know.

DEB: It's often hard to describe how you feel.

DR. LUCAK: Start with when you first noticed those symptoms. How often have you had your issues? Are they constant?

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When you first noticed symptoms

How often you’ve had issues

Are your symptoms constant

KIRK: I knew it was a problem when I went 5 days without going to the bathroom.

DEB: The bloating and the constipation had been the worst.

DR. LUCAK: Any remedies you have tried are important to know. Be sure to make note of any family history as well.

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• OTC regimen
• Supplements & remedies
• Digestive aids

DEB: I have a family history, but I didn’t think to mention that the first time I went to talk about my issues.

DR. LUCAK: Well, let me ask you, how did you all prepare for that first doctor’s appointment?

JULIE: I really didn’t think about it. Now I find it helpful to bring notes with me, and that helps me track my symptoms.

KIRK: Be open and truthful with your doctor because he’s only there to help.

DEB: I started keeping detailed food journals and symptom journals. So here's what I ate, here's how I felt, here's what time of day it was.

DR. LUCAK: That’s the right move. There are a lot of tools out there that can help. It is helpful when patients come prepared to talk about their symptoms. Notes and questionnaires can also help.

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Visit Linzess.com/GutCheck for a personalized discussion guide

DEB: I think when you're trying to seek help, it's really important to advocate for yourself and to have information, like especially when you go to visit a doctor.

DR. LUCAK: Many people with your condition experience the same thing. If you’re experiencing persistent symptoms like constipation with abdominal symptoms, belly pain, discomfort, and bloating, you need to tell your doctor.

KIRK: It’s hard to remember what to say. Time goes by quick.

DEB: You have to go in with a plan.

DR. LUCAK: Here is a plan that will help you make the most of your appointment: bring your notes, talk about your family history, and after you have tried over-the-counter supplements for symptoms that keep coming back, ask if LINZESS is right for you.

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See if LINZESS is right for you

Visit Linzess.com/NextStep

AVO: Watch the next episode to get a better understanding of what to expect when starting LINZESS.

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The Constipation Conversation logo

NEXT UP:

FINDING RELIEF

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USES

LINZESS^® (linaclotide) is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults and functional constipation (FC) in children and adolescents 6 to 17 years of age. “Idiopathic” means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children with functional constipation less than 6 years of age or in children with IBS-C less than 18 years of age.

IMPORTANT RISK INFORMATION

• Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
• Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are:

• Pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
• Breastfeeding or plan to breastfeed. You and your doctor should decide if you will take LINZESS and breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Side Effects

LINZESS can cause serious side effects, including diarrhea, which is the most common side effect and can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.

Other common side effects of LINZESS in people with IBS-C and CIC include gas, stomach-area (abdomen) pain, and swelling, or a feeling of fullness or pressure in your abdomen (distention).

Call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdomen) pain, especially if you also have bright red, bloody stools or black stools that look like tar.

These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie and Ironwood may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.

Please see full Prescribing Information, including Boxed Warning, or visit Abbv.ie/LinzPI

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