SEEKING THE RIGHT TREATMENT VIDEO TRANSCRIPT

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LINZESS logo with Uses and Safety Considerations, along with the first 2 bullets of ISI

USES

LINZESS^® (linaclotide) is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults and functional constipation (FC) in children and adolescents 6 to 17 years of age. “Idiopathic” means the cause of the constipation is unknown. It is not known if LINZESS is safe and effective in children with functional constipation less than 6 years of age or in children with IBS-C less than 18 years of age.

SAFETY CONSIDERATIONS

Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Please see Important Safety Information including Boxed Warning at the end of the video.

Please see full Prescribing Information, including Boxed Warning, or visit Abbv.ie/LinzPI

AVO: We've brought together 3 people to talk about their experience with Irritable Bowel Syndrome with Constipation or IBS-C and Chronic Idiopathic Constipation or CIC.

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DEB | Prescribed LINZESS for IBS-C

KIRK | Prescribed LINZESS for CIC

JULIE | Prescribed LINZESS for CIC

AVO: From when they first started to feel symptoms to finding a treatment that worked for them—

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LINZESS Logo

Presents

AVO: —this is The Constipation Conversation. In this episode, our panel’s sharing their long, frustrating journey with IBS-C and CIC and how it led them to trying LINZESS.

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The Constipation Conversation logo

SEEKING THE RIGHT TREATMENT

EPISODE 2

DEB: I wish I was more present. So many special moments in life that I look back on and all I remember are my gut issues. It’s very frustrating.

JULIE: I’m an avid triathlete. I don’t want to be in the position of feeling constipated on race day or training for triathlons.

KIRK: The constipation was always on my mind. You know, when it developed, and I thought maybe it was just stress and everything like that, but then it just didn’t go away.

JULIE: No one really gets it either. It’s frustrating, and most people—even your closest relatives—don't really understand.

KIRK: No, oh no.

DEB: When I was younger, my belly pain and constipation would get really bad. I have such vivid memories of it.

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Chronic CONSTIPATION and ABDOMINAL SYMPTOMS could be a sign of IBS-C

KIRK: As a funeral director, I’m always on my feet. I remember I was at work, and I hadn’t gone to the bathroom in about 5 days, and I went to the restroom and I was just sitting there, and I kept looking at my watch, and I was like, OK, everybody’s coming in 10 minutes, and I was like, that’s it. I had to do something.

DEB: I just wish I had advocated for myself sooner.

JULIE: That’s the one thing I would push people to do who are dealing with chronic constipation.

DEB: When I got to the doctor, who did take the time with me—we had very good conversations about it, and I felt much more confident and comfortable with knowing what to expect.

KIRK: A lightbulb went off, and I was like, oh, OK, alright. I’m grateful for that moment. Without it I would’ve never have marched myself into the doctor’s office and asked for help.

AVO: Watch episode 3 to get tips on how to have a productive conversation about your gut issues with your doctor. Joining our panel is special guest, Dr. Susan Lucak.

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The Constipation Conversation logo

NEXT UP:

GETTING ON THE SAME PAGE

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USES

IMPORTANT RISK INFORMATION

Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).
Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are:

Pregnant or plan to become pregnant. It is not known if LINZESS will harm your unborn baby.
Breastfeeding or plan to breastfeed. You and your doctor should decide if you will take LINZESS and breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Side Effects

LINZESS can cause serious side effects, including diarrhea, which is the most common side effect and can sometimes be severe. Diarrhea often begins within the first 2 weeks of LINZESS treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with LINZESS.

Other common side effects of LINZESS in people with IBS-C and CIC include gas, stomach-area (abdomen) pain, and swelling, or a feeling of fullness or pressure in your abdomen (distention).

Call your doctor or go to the nearest hospital emergency room right away if you develop unusual or severe stomach-area (abdomen) pain, especially if you also have bright red, bloody stools or black stools that look like tar.

These are not all the possible side effects of LINZESS. For more information, ask your doctor or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie and Ironwood may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.

Please see full Prescribing Information, including Boxed Warning, or visit Abbv.ie/LinzPI

[Abbvie Logo] | [Ironwood Logo]

AbbVie Inc.
1 North Waukegan Road
North Chicago, Illinois 60064-6163

Ironwood^® and its three-leaf design are registered trademarks of Ironwood Pharmaceuticals, Inc. LINZESS^® and its design are registered trademarks of Ironwood Pharmaceuticals, Inc.

*Third-party website; does not constitute an endorsement or recommendation by AbbVie. A fee will be charged by the telemedicine provider.

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IMPORTANT RISK INFORMATION

Do not give LINZESS to children who are less than 2 years of age. It may harm them. LINZESS can cause severe diarrhea and your child could get severe dehydration (loss of a large amount of body water and salt).

Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are:

IMPORTANT RISK INFORMATION

Do not take LINZESS if a doctor has told you that you have a bowel blockage (intestinal obstruction).

Before you take LINZESS, tell your doctor about your medical conditions, including if you are: